In the US, about 30 million cases of migraines are reported each year. Migraines are persistent, pulsing headaches that come with several other difficult symptoms making daily functioning come to a halt. Anyone who has ever experienced a migraine can tell you how intensely painful they can be and how difficult they are to treat. The pain of a migraine typically worsens with exertion. Those suffering often are confined to a quiet, dark room until the pain lets up. Migraines are caused by blood vessels that become enlarged in addition to the release of chemicals from nerve fibers surrounding these vessels.